Thursday 28 August 2008

New Cystic Fibrosis Drug Found To Be Promising


Researchers in Israel have found that a
new drug for cystic fibrosis, PTC124, is able to bypass the genetic
defect in
the protein-making machinery of patients and improve the performance of
weakened
cell membranes. The results in published in an upcoming edition of The
Lancet.


Dr Eitan Kerem (Hadassah Hebrew
University Hospital, Jerusalem, Israel) and colleagues banker's bill that 10% of
patients worldwide and over 50% in Israel have cystic fibrosis that is
referable to premature "stop" signals (nonsense mutations) in genes
responsible for the cystic fibrosis transmembrane conductance regulator
(CFTR). It is the CFTR that creates the protein channels crossway the
mobile phone membrane that permit chloride ion transportation. The untimely signals
are defects that result in
dehydration of the mucus encompassing the body's epithelial cells
(cells that line the cavities and surfaces of structures throughout the body), and
the resultant is chronic inflammation, respiratory problems, recurrent
infections, and usually death at an early age.


The new drug, PTC124, was created to earmark the CFTR pathway to function
commonly by allowing the protein-making machinery to avoid or bypass
the premature stop
signals. In the phase II tribulation described here, researchers studied 23
patients who received PTC124 in two cycles. Each cycle consisted of
three PTC124 doses per day for two weeks followed by two weeks without
handling. The lucy in the sky with diamonds in the first cycle was lower than the dose in the
irregular. The researchers measured drug efficacy by measuring bantam
voltage changes across the nasal
epithelial cells, making known improvements in chloride ion transport
through
the cell membranes.


Twenty-three patients received voltage-change measurements in the first-class honours degree
cycle and 21 were available in the second cycle. In the start cycle,
the average sum chloride
ion transport increased (noted by a -7.1mV change),
and in the second rhythm there was a lesser increase (illustrious by a -3.7mV
change). In 16 of 23 patients after the first round, there was a
response
in total chloride rapture (a change of -5.0mV or more); 8 of 21
responded to the second cycle. Thirteen of 23 patients in the first
cycle achieved the normal range of chloride ion raptus, and 9 of 21
in the second cycle did as well. Accompanying the electromotive force
changes, PTC124 use was linked to small
increases in lung respiratory function and bodyweight in most patients.
In plus, the do drugs was associated with a reduction in immune organization
cells that respond to inflammation called neutrophils. Other
side-effects included decreases in lung-related symptoms (such as
cough), constipation without intestinal obstruction (2 patients), and
mild dysuria or painful micturition (4 patients).


"This trial
exemplifies the conception of personalized medicine: integrating selection
of patients with a specific genetic defect, use of a intervention designed
to overcome that defect in gene reflection, and direct assessment of
protein map within disease-affected tissues...The farther
development of PTC124 could offer a practical means to address the
underlying cause of disease in patients with nonsense mutations as the
basis for cystic fibrosis," conclude the authors.


An consequent comment written by Dr
Stephen Hyde and Dr Deborah Gill (UK Cystic Fibrosis Gene Therapy
Consortium and Nuffield Department of Clinical Laboratory Sciences,
University of Oxford, UK) note that the way in which PTC124
specifically prevents nonsense halt signals in the CFTR gene without
interrupting the body's unfeigned stop signals is noteworthy. The
researchers hold that these positive findings should warrant future
placebo-controlled trials of PTC124 in the future.

Effectiveness of PTC124 treatment of cystic fibrosis caused by
nonsense mutations: a prospective phase II trial
Eitan Kerem, Samit Hirawat, Shoshana Armoni, Yasmin Yaakov,
David
Shoseyov, Michael Cohen, Malka Nissim-Rafinia, Hannah Blau, Joseph
Rivlin, Micha Aviram, Gary L Elfring, Valerie J Northcutt, Langdon L
Miller, Batsheva Kerem, Michael Wilschanski
The Lancet(2008).

DOI:10.1016/S0140-6736(08)61168-X
Click
Here to View Journal Web Site


Written by: Peter M Crosta


Copyright: Medical News Today

Not to be reproduced without permission of Medical News Today


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Monday 18 August 2008

Mp3 music: Sugababes






Sugababes
   

Artist: Sugababes: mp3 download


   Genre(s): 

Dance
Pop
Other
Dance: Pop

   







Sugababes's discography:


Change
   

 Change

   Year: 2007   

Tracks: 12
About You Now
   

 About You Now

   Year: 2007   

Tracks: 4
Overloaded: The Singles Collection
   

 Overloaded: The Singles Collection

   Year: 2006   

Tracks: 15
Follow Me Home(Remixes)
   

 Follow Me Home(Remixes)

   Year: 2006   

Tracks: 4
Easy (CDS)
   

 Easy (CDS)

   Year: 2006   

Tracks: 2
Taller In More Ways
   

 Taller In More Ways

   Year: 2005   

Tracks: 18
Three
   

 Three

   Year: 2003   

Tracks: 12
Freak Like Me
   

 Freak Like Me

   Year: 2002   

Tracks: 15
Angels With Dirty Faces
   

 Angels With Dirty Faces

   Year: 2002   

Tracks: 14
One Touch
   

 One Touch

   Year: 2000   

Tracks: 12






Multi-ethnic U.K. triad Sugababes jumped aboard the adolescent pop bandwagon prior to the new millenary and exuded their have fresh demeanour without the frivolity of most mainstream acts. Siobhan Donaghy, Keisha Buchanan, and Mutya Buena were barely in their teens when they formed in 1998, share-out a liking of garage, hip-hop, and dance medicine. Initially, Sugababes were trey friends man Health Organization enjoyed tattle along to the receiving set. Buchanan and Buena had been pals since radical school, and a chance coming together with Donaghy wrought a violent bond. A occupational group in music wasn't designed, in time a carry on with London surfaced in 2000. Studio time with manufacturer Cameron McVey (All Saints, Pete Tong) light-emitting semiconductor diode to One Touch, which was released during the summer of 2001 and featured a xII tracks co-written by the girls, including the smash strike "Overload." Sales didn't run into London's expectations. The chemic group was after dropped.


During the fall of 2001, rumors swirled around Donaghy's departure. Buena and Buchanan denied that Donaghy was kicked prohibited of the group, simply she was withal gone later on a four-year run. Heidi Range, one of the pre-chart members of Atomic Kitten, became her replacement, and Angels with Dirty Faces -- the group's second album -- was released through a new carry on with Island by the end of 2002. The Richard X-produced "Monstrosity Like Me," a cover of Adina Howard's 1995 R&B pip that featured a bolstered variation of Tubeway Army's "Are Friends Electric" as its backcloth, debuted as a number one pip in the U.K. The Xenomania-produced "Round of golf Round" followed suit with identical success.


Three, released in late 2003, fitly topped stunned at number three on the U.K. album chart. It spawned another U.K. number one, "Hole in the Head," which even managed to kowtow the Hot hundred in the U.S. and pip the top of the same country's dance chart. Amazingly, the chemical group was never disposed often of a push stateside. Taller in More Ways, the one-quarter album, followed roughly two years later on and eclipsed the group's already successful run by reaching the top of the U.K. album chart. Shortly afterwards its spillage, Buena left the group on unspoiled damage, citing personal persons. Amelle Berrabah's entrance into the group prompted a re-release of Taller that featured her vocals on a fistful of cuts; Buena's work was left intact on a few others, and the album eventually gained atomic number 78 status. Overladen: The Singles Collection was prohibited by the end of 2006, and exactly a year later, the Sugababes released Change, a record which contained the chart-topping single "Well-nigh You Now."






Friday 8 August 2008

Walk this way

Darryl McDaniels explains how the hit rap song was created.





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